Myoglobin structure
P02144
MYG_HUMAN
MB

Myoglobin

Homo sapiensTaxon: 9606

3D-structureCytoplasmDirect protein sequencingDisease variantHemeIronMetal-bindingMuscle proteinOxidoreductaseOxygen transportPhosphoproteinProteomics identification+2
序列长度

154

氨基酸

分子量

17.2 kDa

理论值

实验结构

1

PDB 条目

相关疾病

1

已记录

功能描述

Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218)

相关疾病

Myopathy, sarcoplasmic body

An autosomal dominant, slowly progressive muscle disorder manifesting in adulthood with proximal and axial weakness that progresses to involve distal muscles. Patients may lose ambulation after a long disease course, and some individuals develop respiratory or cardiac symptoms. Muscle pathology features include sarcoplasmic bodies in skeletal and cardiac muscles.

氨基酸序列

MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASE
DLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKH
PGDFGADAQGAMNKALELFRKDMASNYKELGFQG

FASTA 格式 · 154 个氨基酸 · 分子量 17.2 kDa

实验结构

1 PDB 条目
3RGK