
P02144
MYG_HUMANMB
Myoglobin
Homo sapiensTaxon: 9606
3D-structureCytoplasmDirect protein sequencingDisease variantHemeIronMetal-bindingMuscle proteinOxidoreductaseOxygen transportPhosphoproteinProteomics identification+2
序列长度
154
氨基酸
分子量
17.2 kDa
理论值
实验结构
1
PDB 条目
相关疾病
1
已记录
功能描述
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218)
相关疾病
Myopathy, sarcoplasmic body
An autosomal dominant, slowly progressive muscle disorder manifesting in adulthood with proximal and axial weakness that progresses to involve distal muscles. Patients may lose ambulation after a long disease course, and some individuals develop respiratory or cardiac symptoms. Muscle pathology features include sarcoplasmic bodies in skeletal and cardiac muscles.
氨基酸序列
MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASE DLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKH PGDFGADAQGAMNKALELFRKDMASNYKELGFQG
FASTA 格式 · 154 个氨基酸 · 分子量 17.2 kDa
实验结构
1 PDB 条目3RGK