P04040
CATA_HUMANCAT
Catalase
Homo sapiensTaxon: 9606
3D-structureAcetylationDirect protein sequencingHemeHydrogen peroxideIronMetal-bindingMitogenNADPOxidoreductasePeroxidasePeroxisome+3
序列长度
527
氨基酸
分子量
59.8 kDa
理论值
实验结构
16
PDB 条目
相关疾病
1
已记录
功能描述
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)
相关疾病
Acatalasemia
A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
氨基酸序列
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
FASTA 格式 · 527 个氨基酸 · 分子量 59.8 kDa
实验结构
16 PDB 条目1DGB1DGF1DGG1DGH1F4J1QQW7P8W7VD98EL98HID8PVD8SGV8WZH8WZJ8WZK8WZM