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Rhodopsin structure
P08100
OPSD_HUMAN
RHO

Rhodopsin

Homo sapiensTaxon: 9606

3D-structureAcetylationCell projectionChromophoreCongenital stationary night blindnessDisease variantDisulfide bondG-protein coupled receptorGlycoproteinLipoproteinMembraneMetal-binding+14
序列长度

348

氨基酸

分子量

38.9 kDa

理论值

实验结构

4

PDB 条目

相关疾病

2

已记录

功能描述

Photoreceptor required for image-forming vision at low light intensity (PubMed:7846071, PubMed:8107847). Required for photoreceptor cell viability after birth (PubMed:12566452, PubMed:2215617). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:26200343, PubMed:28524165, PubMed:28753425, PubMed:8107847). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:26200343, PubMed:28524165)

定位与分布

组织特异性

Rod shaped photoreceptor cells which mediate vision in dim light

相关疾病

Retinitis pigmentosa 4

A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Night blindness, congenital stationary, autosomal dominant 1

A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.

氨基酸序列

MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIP
EGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES

FASTA 格式 · 348 个氨基酸 · 分子量 38.9 kDa

实验结构

4 PDB 条目
4ZWJ5DGY5W0P6CMO

翻译后修饰

  • •Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region (By similarity). After activation by light, phosphorylated by GRK1 (in vitro) (PubMed:28524165)
  • •Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal (PubMed:12566452)