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Vimentin structure
P08670
VIME_HUMAN
VIM

Vimentin

Homo sapiensTaxon: 9606

3D-structureAcetylationCataractCell membraneCell projectionCoiled coilCytoplasmCytoskeletonDirect protein sequencingDisease variantGlycoproteinHost-virus interaction+9
序列长度

466

氨基酸

分子量

53.7 kDa

理论值

实验结构

26

PDB 条目

相关疾病

1

已记录

功能描述

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity) Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2

定位与分布

组织特异性

Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines

相关疾病

Cataract 30, multiple types

An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.

氨基酸序列

MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV
YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK
VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE

FASTA 格式 · 466 个氨基酸 · 分子量 53.7 kDa

实验结构

26 PDB 条目
1GK41GK61GK73G1E3KLT3S4R3SSU3SWK3TRT3UF14MCY4MCZ4MD04MD54MDI4MDJ4YPC4YV35WHF6ATF6ATI6BIR6YXK8RVE8TRQ8TRR

翻译后修饰

  • •Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm (PubMed:21465480). Phosphorylated by STK33 (PubMed:18811945). Phosphorylated on tyrosine residues by SRMS (PubMed:29496907)
  • •O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status
  • •S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex