D(1A) dopamine receptor

Homo sapiensTaxon: 9606

3D-structureCell membraneCell projectionDisulfide bondEndoplasmic reticulumG-protein coupled receptorGlycoproteinLipoproteinMembranePalmitateProteomics identificationReceptor+5

序列长度

446

氨基酸

分子量

49.3 kDa

理论值

实验结构

PDB 条目

功能描述

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity

定位与分布

组织特异性

Detected in caudate, nucleus accumbens and in the olfactory tubercle

氨基酸序列

MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN

FASTA 格式 · 446 个氨基酸 · 分子量 49.3 kDa

实验结构

24 PDB 条目

7CKW7CKX7CKY7CKZ7CRH7F0T7F1O7F1Z7F237F247JOZ7JV57JVP7JVQ7LJC7LJD7X2C7X2D7X2F8IRR8JXR8JXS9I529I54